Abstract
The hemogram parameters have been extensively discussed in numerous diseases, including
epilepsy, for their diagnostic and prognostic values. We aimed to investigate the
impact of hemogram parameters, namely, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte
ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) at the time of the first seizure
on the remission durations of the patients with self-limited epilepsy with centrotemporal
spikes (SeLECTS). This retrospective study was conducted on patients with SeLECTS
with a minimum follow-up of 2 years. We assessed the hemogram parameters obtained
from the venous blood samples collected from the patients upon admission. The duration
of remission was categorized into two groups for further data analysis: those with
a remission period less than 2 years and those with a remission period of more than
2 years. This study involved 122 patients with SeLECTS, of which 85% (n = 102) had remission durations of ≤2 years. The analysis revealed that patients with
remission durations exceeding 2 years had a significantly higher median leukocyte
(p = 0.009), neutrophil (p < 0.001), and platelet (p < 0.001) counts. Additionally, higher levels of NLR and PLR were observed in patients
with longer-term remission (p < 0.001). However, there were no significant differences between the two groups in
terms of lymphocyte count, monocyte count, mean platelet volume, or LMR. Leukocyte,
neutrophil, platelet, NLR, and PLR counts have shown potential as predictive indicators
of remission times in patients with SeLECTS. Neurologists can potentially find value
in these easily accessible parameters when evaluating the future trajectory of patients
with SeLECTS.
Keywords
epilepsy - hemogram - leukocyte count - rolandic epilepsy - self-limited epilepsy
with centrotemporal spikes
